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Buy Bocouture (1x50iu) online botulinum toxin (BTX), also botulinum neurotoxin (BoNT), botulism toxin, botulinum toxin, botulin, trade name for BTX-A for example botox, is a collective term for several very similar neurotoxic proteins. The neurotoxins are excreted by different strains of the bacterial species Clostridium botulinum, Clostridium butyricum, Clostridium baratii and Clostridium argentinense and are therefore exotoxins. The poisonous effect of these proteins is based on the inhibition of the transmission of excitation by nerve cells, which, in addition to disorders of the vegetative nervous system, can in particular result in muscle weakness or even in the stoppage of the lung function. For higher organisms, botulinum toxin is by far the deadliest known poison. The LD50 values for mice are 30 pg / kg (0.03 ng / kg) with intravenous administration to 4 ng / kg with subcutaneous intake. When inhaled, 3 ng / kg are already fatal.
While the C. botulinum used to be feared as the cause of food poisoning botulism, the proteins it produces have also been used for medical purposes since the 1980s, primarily for the treatment of neurological movement disorders (dystonia). The use in cosmetic medicine for the temporary weakening of wrinkles (duration 3–6 months) has been heavily criticized because of the resulting massive increase in animal experiments. There is also a risk of serious nerve damage without medical intervention.
C. botulinum is ubiquitous, especially in the soil. Tetanus toxin, which is produced by Clostridium tetani, has a similar structure.
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